Review
Abstract
The congenital long QT syndrome is a rare disorder in which mutation carriers are at risk for polymorphic ventricular tachycardia and/or sudden cardiac death. Discovery and analysis of gene mutations associated with variants of this disorder have provided novel insight into mechanisms of cardiac arrhythmia and have raised the possibility of mutation-specific therapeutic intervention.
Authors
Robert S. Kass, Arthur J. Moss
Abstract
Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving. This review discusses the search for effective therapeutic interventions, hurdles in translational sepsis research, and new therapies in development in current clinical trials.
Authors
Niels C. Riedemann, Ren-Feng Guo, Peter A. Ward
Abstract
Authors
Daniel J. Rader, Jonathan Cohen, Helen H. Hobbs
Abstract
Authors
Judith Korner, Louis J. Aronne
Abstract
Authors
Jack A. Elias, Chun Geun Lee, Tao Zheng, Bing Ma, Robert J. Homer, Zhou Zhu
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ISSN: 0021-9738 (print), 1558-8238 (online)