Age‐related expression, enzymatic solubility and modification with advanced glycation end‐products of fibrillar collagens in mouse lung
P Rolewska, S Al-Robaiy, AN Santos, A Simm… - Experimental …, 2013 - Elsevier
Changes in the expression of fibrillar collagens and post-translational modifications with
advanced glycation end-products (AGEs) are often associated with tissue aging. Less is
known about age-related changes in mouse lung tissue. Therefore, we studied the
expression level and AGE load of fibrillar collagens in lungs from young (≤ 6months), adult
(15months) and old (≥ 25months) mice. The mRNA expression level was reduced in adult
and old mice compared with the young. Old mice also showed a reduced protein level …
advanced glycation end-products (AGEs) are often associated with tissue aging. Less is
known about age-related changes in mouse lung tissue. Therefore, we studied the
expression level and AGE load of fibrillar collagens in lungs from young (≤ 6months), adult
(15months) and old (≥ 25months) mice. The mRNA expression level was reduced in adult
and old mice compared with the young. Old mice also showed a reduced protein level …