The demonstration in model organisms that cellular senescence drives aging and age-
related diseases has led to widespread efforts to identify compounds able to selectively kill
senescent cells, termed senolytics. Approaches used to identify senolytics include
bioinformatic analysis of senescent cell anti-apoptotic pathways (SCAPs) for drug
development and screening of drugs libraries on different senescent cell types in culture.
Alternatively, cytotoxic compounds can be made specific to senescent cells through a …