Human alveolar macrophages induce functional inactivation in antigen-specific CD4 T cells
RL Blumenthal, DE Campbell, P Hwang… - Journal of Allergy and …, 2001 - Elsevier
Background: Alveolar macrophages (AMCs) are the most abundant phagocytic cells in the
lung, but they present antigen poorly to T cells. Objectives: The objectives of our studies
were to more clearly define the mechanisms by which AMCs present antigen to T cells and
to determine whether AMCs actively inhibit T-cell activation. Methods: We studied purified
human CD4 T cells and compared the capacity of allogeneic AMCs and peripheral blood
monocytes to induce T-cell proliferation and cytokine production. Results: We previously …
lung, but they present antigen poorly to T cells. Objectives: The objectives of our studies
were to more clearly define the mechanisms by which AMCs present antigen to T cells and
to determine whether AMCs actively inhibit T-cell activation. Methods: We studied purified
human CD4 T cells and compared the capacity of allogeneic AMCs and peripheral blood
monocytes to induce T-cell proliferation and cytokine production. Results: We previously …