Mechanisms of resistance to delamanid, a drug for Mycobacterium tuberculosis
M Fujiwara, M Kawasaki, N Hariguchi, Y Liu… - Tuberculosis, 2018 - Elsevier
Delamanid, a bicyclic nitroimidazooxazole, is effective against M. tuberculosis. Previous
studies have shown that resistance to a bicyclic nitroimidazooxazine, PA-824, is caused by
mutations in an F 420-dependent bio-activation pathway. We investigated whether the same
mechanisms are responsible for resistance to delamanid. Spontaneous resistance
frequencies were determined using M. bovis BCG Tokyo (BCG) and M. tuberculosis H37Rv.
F 420 high-performance liquid chromatography (HPLC) elution patterns of homogenates of …
studies have shown that resistance to a bicyclic nitroimidazooxazine, PA-824, is caused by
mutations in an F 420-dependent bio-activation pathway. We investigated whether the same
mechanisms are responsible for resistance to delamanid. Spontaneous resistance
frequencies were determined using M. bovis BCG Tokyo (BCG) and M. tuberculosis H37Rv.
F 420 high-performance liquid chromatography (HPLC) elution patterns of homogenates of …