Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
TT Junttila, G Li, K Parsons, GL Phillips… - Breast cancer research …, 2011 - Springer
TT Junttila, G Li, K Parsons, GL Phillips, MX Sliwkowski
Breast cancer research and treatment, 2011•SpringerTrastuzumab (Herceptin®) is currently used as a treatment for patients whose breast tumors
overexpress HER2/ErbB2. Trastuzumab-DM1 (T-DM1, trastuzumab emtansine) is designed
to combine the clinical benefits of trastuzumab with a potent microtubule-disrupting drug,
DM1 (a maytansine derivative). Currently T-DM1 is being tested in multiple clinical trials. The
mechanisms of action for trastuzumab include inhibition of PI3K/AKT signaling pathway,
inhibition of HER-2 shedding and Fcγ receptor mediated engagement of immune cells …
overexpress HER2/ErbB2. Trastuzumab-DM1 (T-DM1, trastuzumab emtansine) is designed
to combine the clinical benefits of trastuzumab with a potent microtubule-disrupting drug,
DM1 (a maytansine derivative). Currently T-DM1 is being tested in multiple clinical trials. The
mechanisms of action for trastuzumab include inhibition of PI3K/AKT signaling pathway,
inhibition of HER-2 shedding and Fcγ receptor mediated engagement of immune cells …
Abstract
Trastuzumab (Herceptin®) is currently used as a treatment for patients whose breast tumors overexpress HER2/ErbB2. Trastuzumab-DM1 (T-DM1, trastuzumab emtansine) is designed to combine the clinical benefits of trastuzumab with a potent microtubule-disrupting drug, DM1 (a maytansine derivative). Currently T-DM1 is being tested in multiple clinical trials. The mechanisms of action for trastuzumab include inhibition of PI3K/AKT signaling pathway, inhibition of HER-2 shedding and Fcγ receptor mediated engagement of immune cells, which may result in antibody-dependent cellular cytotoxicity (ADCC). Here we report that T-DM1 retains the mechanisms of action of unconjugated trastuzumab and is active against lapatinib resistant cell lines and tumors.
Springer
