The analysis of analytical ultracentrifugation (AUC) data has been greatly facilitated by the
advances accumulated in recent years. These improvements include refinements in AUC-
based binding isotherms, advances in the fitting of both sedimentation velocity (SV) and
sedimentation equilibrium (SE) data, and innovations in calculations related to
posttranslationally modified proteins and to proteins with a large amount of associated
cosolute, eg, detergents. To capitalize on these advances, the experimenter often must …