The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1. 5 and RyR2 function
CN Johnson, R Pattanayek, F Potet, RT Rebbeck… - Cell Calcium, 2019 - Elsevier
Here we report the structure of the widely utilized calmodulin (CaM)-dependent protein
kinase II (CaMKII) inhibitor KN93 bound to the Ca 2+-sensing protein CaM. KN93 is widely
believed to inhibit CaMKII by binding to the kinase. The CaM-KN93 interaction is significant
as it can interfere with the interaction between CaM and it's physiological targets, thereby
raising the possibility of ascribing modified protein function to CaMKII phosphorylation while
concealing a CaM–protein interaction. NMR spectroscopy, stopped-flow kinetic …
kinase II (CaMKII) inhibitor KN93 bound to the Ca 2+-sensing protein CaM. KN93 is widely
believed to inhibit CaMKII by binding to the kinase. The CaM-KN93 interaction is significant
as it can interfere with the interaction between CaM and it's physiological targets, thereby
raising the possibility of ascribing modified protein function to CaMKII phosphorylation while
concealing a CaM–protein interaction. NMR spectroscopy, stopped-flow kinetic …