Most proteomic studies use liquid chromatography coupled to tandem mass spectrometry to
identify and quantify the peptides generated by the proteolysis of a biological sample.
However, with the current methods it remains challenging to rapidly, consistently,
reproducibly, accurately, and sensitively detect and quantify large fractions of proteomes
across multiple samples. Here we present a new strategy that systematically queries sample
sets for the presence and quantity of essentially any protein of interest. It consists of using …