Liver fatty acid-binding protein (L-Fabp) is an abundant cytosolic lipid-binding protein with
broad substrate specificity, expressed in mammalian enterocytes and hepatocytes. We have
generated mice with a targeted deletion of the endogenous L-Fabp gene and have
characterized their response to alterations in hepatic fatty acid flux following prolonged
fasting. Chow-fed L-Fabp–/–mice were indistinguishable from wild-type littermates with
regard to growth, serum and tissue lipid profiles, and fatty acid distribution within hepatic …