Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway
B Sun, C Dong, H Lei, Y Gong, M Li, Y Zhang… - Chemico-biological …, 2018 - Elsevier
Infantile hemangioma (IH) is one of the most common benign vascular tumors of infancy.
Propranolol has been recently introduced for the treatment of IH. However, the mechanism
of protective effect has not been fully understood. In this study, hemangioma-derived
endothelial cells (HemECs) were isolated and treated with propranolol. The cell viability was
measured by MTT assay, and the cell cycle arrest was detected using flow cytometry. Cell
invasion was determined using transwell assay. The expressions of matrix …
Propranolol has been recently introduced for the treatment of IH. However, the mechanism
of protective effect has not been fully understood. In this study, hemangioma-derived
endothelial cells (HemECs) were isolated and treated with propranolol. The cell viability was
measured by MTT assay, and the cell cycle arrest was detected using flow cytometry. Cell
invasion was determined using transwell assay. The expressions of matrix …