[HTML][HTML] The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18
BM Hosking, SCM Wang, M Downes… - Journal of Biological …, 2004 - ASBMB
VCAM-1 (vascular cell adhesion molecule-1) and Sox18 are involved in vascular
development. VCAM-1 is an important adhesion molecule that is expressed on endothelial
cells and has a critical role in endothelial activation, inflammation, lymphatic
pathophysiology, and atherogenesis. The Sry-related high mobility group box factor Sox18
has previously been implicated in endothelial pathologies. Mutations in human and mouse
Sox18 leads to hypotrichosis and lymphedema. Furthermore, both Sox18 and VCAM-1 have …
development. VCAM-1 is an important adhesion molecule that is expressed on endothelial
cells and has a critical role in endothelial activation, inflammation, lymphatic
pathophysiology, and atherogenesis. The Sry-related high mobility group box factor Sox18
has previously been implicated in endothelial pathologies. Mutations in human and mouse
Sox18 leads to hypotrichosis and lymphedema. Furthermore, both Sox18 and VCAM-1 have …