Bioengineering human microvascular networks in immunodeficient mice
RZ Lin, JM Melero-Martin - JoVE (Journal of Visualized Experiments), 2011 - jove.com
The future of tissue engineering and cell-based therapies for tissue regeneration will likely
rely on our ability to generate functional vascular networks in vivo. In this regard, the search
for experimental models to build blood vessel networks in vivo is of utmost importance 1.
The feasibility of bioengineering microvascular networks in vivo was first shown using
human tissue-derived mature endothelial cells (ECs) 2-4; however, such autologous
endothelial cells present problems for wide clinical use, because they are difficult to obtain …
rely on our ability to generate functional vascular networks in vivo. In this regard, the search
for experimental models to build blood vessel networks in vivo is of utmost importance 1.
The feasibility of bioengineering microvascular networks in vivo was first shown using
human tissue-derived mature endothelial cells (ECs) 2-4; however, such autologous
endothelial cells present problems for wide clinical use, because they are difficult to obtain …