Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular
metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low
oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent
signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular
stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver
disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular …