[HTML][HTML] Mapping the sites of the lipoprotein lipase (LPL)–angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition
AR Gutgsell, SV Ghodge, AA Bowers… - Journal of Biological …, 2019 - ASBMB
Cardiovascular disease has been the leading cause of death throughout the world for nearly
2 decades. Hypertriglyceridemia affects more than one-third of the population in the United
States and is an independent risk factor for cardiovascular disease. Despite the frequency of
hypertriglyceridemia, treatment options are primarily limited to diet and exercise. Lipoprotein
lipase (LPL) is an enzyme responsible for clearing triglycerides from circulation, and its
activity alone can directly control plasma triglyceride concentrations. Therefore, LPL is a …
2 decades. Hypertriglyceridemia affects more than one-third of the population in the United
States and is an independent risk factor for cardiovascular disease. Despite the frequency of
hypertriglyceridemia, treatment options are primarily limited to diet and exercise. Lipoprotein
lipase (LPL) is an enzyme responsible for clearing triglycerides from circulation, and its
activity alone can directly control plasma triglyceride concentrations. Therefore, LPL is a …