Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver
A Guillot, N Hamdaoui, A Bizy, K Zoltani, R Souktani… - Hepatology, 2014 - journals.lww.com
Abstract Interleukin (IL)-17 is a proinflammatory and fibrogenic cytokine mainly produced by
T-helper (Th) 17 lymphocytes, together with the hepatoprotective and antifibrogenic
cytokine, IL-22. Cannabinoid receptor 2 (CB2) is predominantly expressed in immune cells
and displays anti-inflammatory and antifibrogenic effects. In the present study, we further
investigated the mechanism underlying antifibrogenic properties of CB2 receptor and
explored its effect on the profibrogenic properties of IL-17. After bile duct ligation (BDL), the …
T-helper (Th) 17 lymphocytes, together with the hepatoprotective and antifibrogenic
cytokine, IL-22. Cannabinoid receptor 2 (CB2) is predominantly expressed in immune cells
and displays anti-inflammatory and antifibrogenic effects. In the present study, we further
investigated the mechanism underlying antifibrogenic properties of CB2 receptor and
explored its effect on the profibrogenic properties of IL-17. After bile duct ligation (BDL), the …