25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages
N Shibata, AF Carlin, NJ Spann, K Saijo… - Journal of Biological …, 2013 - ASBMB
25-Hydroxycholesterol (25OHC) is an enzymatically derived oxidation product of cholesterol
that modulates lipid metabolism and immunity. 25OHC is synthesized in response to
interferons and exerts broad antiviral activity by as yet poorly characterized mechanisms. To
gain further insights into the basis for antiviral activity, we evaluated time-dependent
responses of the macrophage lipidome and transcriptome to 25OHC treatment. In addition to
altering specific aspects of cholesterol and sphingolipid metabolism, we found that 25OHC …
that modulates lipid metabolism and immunity. 25OHC is synthesized in response to
interferons and exerts broad antiviral activity by as yet poorly characterized mechanisms. To
gain further insights into the basis for antiviral activity, we evaluated time-dependent
responses of the macrophage lipidome and transcriptome to 25OHC treatment. In addition to
altering specific aspects of cholesterol and sphingolipid metabolism, we found that 25OHC …
