[HTML][HTML] Prostaglandin signaling in the renal collecting duct: release, reuptake, and oxidation in the same cell

T Nomura, HY Chang, R Lu, J Hankin… - Journal of Biological …, 2005 - ASBMB
Prostaglandins mediate autacrine and paracrine signaling over short distances. We used
the renal collecting duct as a model system to test the hypothesis that local control of
prostaglandin signaling is achieved by expressing inactivation in the same cell as synthesis.
Immunocytochemical studies demonstrated that renal collecting ducts in situ express the
prostaglandin (PG) synthesis enzyme, cyclooxygenase-1 (COX-1), as well as both
components of prostaglandin metabolic inactivation, ie the prostaglandin uptake carrier …