[HTML][HTML] The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion
JW Joseph, MV Jensen, O Ilkayeva, F Palmieri… - Journal of Biological …, 2006 - ASBMB
Glucose-stimulated insulin secretion (GSIS) is mediated in part by glucose metabolism-
driven increases in ATP/ADP ratio, but by-products of mitochondrial glucose metabolism
also play an important role. Here we investigate the role of the mitochondrial citrate/isocitrate
carrier (CIC) in regulation of GSIS. Inhibition of CIC activity in INS-1-derived 832/13 cells or
primary rat islets by the substrate analogue 1, 2, 3-benzenetricarboxylate (BTC) resulted in
potent inhibition of GSIS, involving both first and second phase secretion. A recombinant …
driven increases in ATP/ADP ratio, but by-products of mitochondrial glucose metabolism
also play an important role. Here we investigate the role of the mitochondrial citrate/isocitrate
carrier (CIC) in regulation of GSIS. Inhibition of CIC activity in INS-1-derived 832/13 cells or
primary rat islets by the substrate analogue 1, 2, 3-benzenetricarboxylate (BTC) resulted in
potent inhibition of GSIS, involving both first and second phase secretion. A recombinant …