[HTML][HTML] Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1, 4, 5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) …
Angiotensin II (ANG II) stimulates renal tubular reabsorption of NaCl by targeting Na+/H+
exchanger NHE3. We have shown previously that inositol 1, 4, 5-triphosphate receptor-
binding protein released with inositol 1, 4, 5-triphosphate (IRBIT) plays a critical role in
stimulation of NHE3 in response to elevated intracellular Ca 2+ concentration ([Ca 2+] i). In
this study, we investigated the role of IRBIT in mediating NHE3 activation by ANG II. IRBIT is
abundantly expressed in the proximal tubules where NHE3 is located. ANG II at …
exchanger NHE3. We have shown previously that inositol 1, 4, 5-triphosphate receptor-
binding protein released with inositol 1, 4, 5-triphosphate (IRBIT) plays a critical role in
stimulation of NHE3 in response to elevated intracellular Ca 2+ concentration ([Ca 2+] i). In
this study, we investigated the role of IRBIT in mediating NHE3 activation by ANG II. IRBIT is
abundantly expressed in the proximal tubules where NHE3 is located. ANG II at …