[HTML][HTML] IRBIT, inositol 1, 4, 5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to …
Calcium (Ca 2+) is a highly versatile second messenger that regulates various cellular
processes. Previous studies showed that elevation of intracellular Ca 2+ regulates the
activity of Na+/H+ exchanger 3 (NHE3). However, the effect of Ca 2+-dependent signaling
on NHE3 activity varies depending on cell types. In this study, we report the identification of
IP 3 receptor-binding protein released with IP 3 (IRBIT) as a NHE3 interacting protein and its
role in regulation of NHE3 activity. IRBIT bound to the carboxyl-terminal domain of NHE3 …
processes. Previous studies showed that elevation of intracellular Ca 2+ regulates the
activity of Na+/H+ exchanger 3 (NHE3). However, the effect of Ca 2+-dependent signaling
on NHE3 activity varies depending on cell types. In this study, we report the identification of
IP 3 receptor-binding protein released with IP 3 (IRBIT) as a NHE3 interacting protein and its
role in regulation of NHE3 activity. IRBIT bound to the carboxyl-terminal domain of NHE3 …