[HTML][HTML] Coagulation factor XII protease domain crystal structure
M Pathak, P Wilmann, J Awford, C Li, BK Hamad… - Journal of Thrombosis …, 2015 - Elsevier
Background Coagulation factor XII is a serine protease that is important for kinin generation
and blood coagulation, cleaving the substrates plasma kallikrein and FXI. Objective To
investigate FXII zymogen activation and substrate recognition by determining the crystal
structure of the FXII protease domain. Methods and results A series of recombinant FXII
protease constructs were characterized by measurement of cleavage of chromogenic
peptide and plasma kallikrein protein substrates. This revealed that the FXII protease …
and blood coagulation, cleaving the substrates plasma kallikrein and FXI. Objective To
investigate FXII zymogen activation and substrate recognition by determining the crystal
structure of the FXII protease domain. Methods and results A series of recombinant FXII
protease constructs were characterized by measurement of cleavage of chromogenic
peptide and plasma kallikrein protein substrates. This revealed that the FXII protease …