[HTML][HTML] Obesity and the neuroendocrine control of energy homeostasis: the role of spontaneous locomotor activity
TR Castaneda, H Jürgens, P Wiedmer, P Pfluger… - The Journal of …, 2005 - Elsevier
Obesity represents one of the most urgent global health threats as well as one of the leading
causes of death throughout industrialized nations. Efficacious and safe therapies remain at
large. Attempts to decrease fat mass via pharmacological reduction of energy intake have
had limited potency or intolerable side effects. Increasingly widespread sedentary lifestyle is
often cited as a major contributor to the increasing prevalence of obesity. Moreover, low
levels of spontaneous physical activity (SPA) are a major predictor of fat mass accumulation …
causes of death throughout industrialized nations. Efficacious and safe therapies remain at
large. Attempts to decrease fat mass via pharmacological reduction of energy intake have
had limited potency or intolerable side effects. Increasingly widespread sedentary lifestyle is
often cited as a major contributor to the increasing prevalence of obesity. Moreover, low
levels of spontaneous physical activity (SPA) are a major predictor of fat mass accumulation …