Bilateral implants of estradiol benzoate into the corticomedial nuclei of the amygdala significantly reduced food intake in ovariectomised rats over a 72-hour stimulation period. The effect was similar in magnitude to those following diencephalic estrogen implants. A decrease in food intake was also observed following amygdaloid estradiol benzoate implants in ovariectomised rats which had previously sustained electrolytic lesions of the ventromedial-arcuate region of the hypothalamus. It is concluded that estradiol benzoate may act directly on both the hypothalamus and amygdala (as well as peripherally) to modulate food intake.