Estradiol acts in the medial preoptic area, arcuate nucleus, and dorsal raphe nucleus to reduce food intake in ovariectomized rats
J Santollo, AM Torregrossa, LA Eckel - Hormones and behavior, 2011 - Elsevier
Estradiol (E2) exerts an inhibitory effect on food intake in a variety of species. While
compelling evidence indicates that central, rather than peripheral, estrogen receptors (ERs)
mediate this effect, the exact brain regions involved have yet to be conclusively identified. In
order to identify brain regions that are sufficient for E2's anorectic effect, food intake was
monitored for 48h following acute, unilateral, microinfusions of vehicle and two doses (0.25
and 2.5 μg) of a water-soluble form of E2 in multiple brain regions within the hypothalamus …
compelling evidence indicates that central, rather than peripheral, estrogen receptors (ERs)
mediate this effect, the exact brain regions involved have yet to be conclusively identified. In
order to identify brain regions that are sufficient for E2's anorectic effect, food intake was
monitored for 48h following acute, unilateral, microinfusions of vehicle and two doses (0.25
and 2.5 μg) of a water-soluble form of E2 in multiple brain regions within the hypothalamus …