Gonadotropin-releasing hormone (GnRH) neuron migration: initiation, maintenance and cessation as critical steps to ensure normal reproductive function
ME Wierman, K Kiseljak-Vassiliades, S Tobet - Frontiers in …, 2011 - Elsevier
GnRH neurons follow a carefully orchestrated journey from their birth in the olfactory
placode area. Initially, they migrate along with the vomeronasal nerve into the brain at the
cribriform plate, then progress caudally to sites within the hypothalamus where they halt and
send projections to the median eminence to activate pituitary gonadotropes. Many factors
controlling this precise journey have been elucidated by the silencing or over-expression of
candidate genes in mouse models. Importantly, a number of these factors may not only play …
placode area. Initially, they migrate along with the vomeronasal nerve into the brain at the
cribriform plate, then progress caudally to sites within the hypothalamus where they halt and
send projections to the median eminence to activate pituitary gonadotropes. Many factors
controlling this precise journey have been elucidated by the silencing or over-expression of
candidate genes in mouse models. Importantly, a number of these factors may not only play …