The proteasome is the major cellular proteolytic machinery responsible for the degradation
of both normal and damaged proteins. Proteasomes play a fundamental role in retaining
cellular homeostasis. Alterations of proteasome function have been recorded in various
biological phenomena including aging. We have recently shown that the decrease in
proteasome activity in senescent human fibroblasts relates to the down-regulation of β-type
subunits. In this study we have followed our preliminary observation by developing and …