[PDF][PDF] Extreme makeover: converting one cell into another
Q Zhou, DA Melton - Cell stem cell, 2008 - cell.com
Q Zhou, DA Melton
Cell stem cell, 2008•cell.comCells of adult mammals can be converted (reprogrammed) to new cells. In one approach,
adult cells are converted to pluripotent stem cells, followed by differentiation to regenerate
new cell types. Alternatively, adult cells may be directly converted into other mature cells or
progenitors. We discuss and compare these two approaches with particular emphasis on the
latter and its relevance for regenerative medicine.
adult cells are converted to pluripotent stem cells, followed by differentiation to regenerate
new cell types. Alternatively, adult cells may be directly converted into other mature cells or
progenitors. We discuss and compare these two approaches with particular emphasis on the
latter and its relevance for regenerative medicine.
Summary
Cells of adult mammals can be converted (reprogrammed) to new cells. In one approach, adult cells are converted to pluripotent stem cells, followed by differentiation to regenerate new cell types. Alternatively, adult cells may be directly converted into other mature cells or progenitors. We discuss and compare these two approaches with particular emphasis on the latter and its relevance for regenerative medicine.
cell.com
