Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune uveoretinitis
Experimental autoimmune uveoritinitis (EAU) is a protitypic T cell-mediated autoimmune
disease, whose target tissue is the nueral retina, that is used as a model for a number of
human blinding ocular diseases of a presumed autoimmune nature. EAU in rats can be
induced by adoptive transfer of small numbers of retinal antigen-specific CD4+ T cell lines.
Although recruitment mechanisms were assumed to play a role in the immunopathogenesis
of uveitis, there is no direct evidence that would permit assessment of the importance of …
disease, whose target tissue is the nueral retina, that is used as a model for a number of
human blinding ocular diseases of a presumed autoimmune nature. EAU in rats can be
induced by adoptive transfer of small numbers of retinal antigen-specific CD4+ T cell lines.
Although recruitment mechanisms were assumed to play a role in the immunopathogenesis
of uveitis, there is no direct evidence that would permit assessment of the importance of …
