[HTML][HTML] Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
IM Ward, K Minn, KG Jorda, J Chen - Journal of Biological Chemistry, 2003 - ASBMB
53BP1 participates in the cellular response to DNA damage. Like many proteins involved in
the DNA damage response, 53BP1 becomes hyperphosphorylated after radiation and
colocalizes with phosphorylated H2AX in megabase regions surrounding the sites of DNA
strand breaks. However, it is not yet clear whether the phosphorylation status of 53BP1
determines its localization or vice versa. In this study we mapped a region upstream of the
53BP1 C terminus that is required and sufficient for the recruitment of 53BP1 to these DNA …
the DNA damage response, 53BP1 becomes hyperphosphorylated after radiation and
colocalizes with phosphorylated H2AX in megabase regions surrounding the sites of DNA
strand breaks. However, it is not yet clear whether the phosphorylation status of 53BP1
determines its localization or vice versa. In this study we mapped a region upstream of the
53BP1 C terminus that is required and sufficient for the recruitment of 53BP1 to these DNA …
