[HTML][HTML] Familial hypertrophic cardiomyopathy mutations from different functional regions of troponin T result in different effects on the pH and Ca2+ sensitivity of …
K Harada, JD Potter - Journal of Biological Chemistry, 2004 - ASBMB
To understand the molecular function of troponin T (TnT) in the Ca 2+ regulation of muscle
contraction as well as the molecular pathogenesis of familial hypertrophic cardiomyopathy
(FHC), eight FHC-linked TnT mutations, which are located in different functional regions of
human cardiac TnT (HCTnT), were produced, and their structural and functional properties
were examined. Circular dichroism spectroscopy demonstrated different secondary
structures of these TnT mutants. Each of the recombinant HCTnTs was incorporated into …
contraction as well as the molecular pathogenesis of familial hypertrophic cardiomyopathy
(FHC), eight FHC-linked TnT mutations, which are located in different functional regions of
human cardiac TnT (HCTnT), were produced, and their structural and functional properties
were examined. Circular dichroism spectroscopy demonstrated different secondary
structures of these TnT mutants. Each of the recombinant HCTnTs was incorporated into …