[HTML][HTML] Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and …
UK Misra, SV Pizzo - Journal of biological chemistry, 2005 - ASBMB
In this study, we have examined the role of two cAMP downstream effectors protein kinase A
(PKA) and Epac, in forskolin-induced macrophage proliferation. Treatment of macrophages
with forskolin enhanced [3 H] thymidine uptake and increased cell number, and both were
profoundly reduced by prior treatment of cells with H-89, a specific PKA inhibitor. Incubation
of macrophages with forskolin triggered the activation of Akt, predominantly by
phosphorylation of Ser-473, as measured by Western blotting and assay of its kinase …
(PKA) and Epac, in forskolin-induced macrophage proliferation. Treatment of macrophages
with forskolin enhanced [3 H] thymidine uptake and increased cell number, and both were
profoundly reduced by prior treatment of cells with H-89, a specific PKA inhibitor. Incubation
of macrophages with forskolin triggered the activation of Akt, predominantly by
phosphorylation of Ser-473, as measured by Western blotting and assay of its kinase …
