A multicenter study of the effect of solution temperature on nasal potential difference measurements
Background Nasal potential difference (PD) measurement quantifies the abnormal sodium
and chloride transport that is characteristic of cystic fibrosis (CF) and has gained acceptance
as both a diagnostic tool and outcome measure for new CF therapies. Because small
changes in nasal PD-measured chloride transport are often an important component in
evaluating new CF therapies, techniques to maximize sensitivity and reproducibility are
essential. Study objective To determine if administration of warmed nasal PD solutions (37° …
and chloride transport that is characteristic of cystic fibrosis (CF) and has gained acceptance
as both a diagnostic tool and outcome measure for new CF therapies. Because small
changes in nasal PD-measured chloride transport are often an important component in
evaluating new CF therapies, techniques to maximize sensitivity and reproducibility are
essential. Study objective To determine if administration of warmed nasal PD solutions (37° …