Angiogenesis in implantation
DS Torry, J Leavenworth, M Chang… - Journal of assisted …, 2007 - Springer
DS Torry, J Leavenworth, M Chang, V Maheshwari, K Groesch, ER Ball, RJ Torry
Journal of assisted reproduction and genetics, 2007•SpringerProblem Implantation failure and early pregnancy loss are common following natural
conceptions and they are particularly important clinical hurdles to overcome following
assisted reproduction attempts. The importance of adequate vascular development and
maintenance during implantation has recently become a major focus of investigation.
Materials and methods Review of current published literature was undertaken to summerize
the cells and cell products that regulate tissue vascularity during implantation. Results …
conceptions and they are particularly important clinical hurdles to overcome following
assisted reproduction attempts. The importance of adequate vascular development and
maintenance during implantation has recently become a major focus of investigation.
Materials and methods Review of current published literature was undertaken to summerize
the cells and cell products that regulate tissue vascularity during implantation. Results …
Problem
Implantation failure and early pregnancy loss are common following natural conceptions and they are particularly important clinical hurdles to overcome following assisted reproduction attempts. The importance of adequate vascular development and maintenance during implantation has recently become a major focus of investigation.
Materials and methods
Review of current published literature was undertaken to summerize the cells and cell products that regulate tissue vascularity during implantation.
Results
Vascular development at the maternal fetal interface can be regulated by a number of different cell types; two principal candidates are trophoblast and natural killer cells. A wide range of soluble factors, some with well established angiogenic functions as well as other more novel factors, can contribute to vascular development and maintenance at the maternal–fetal interface.
Conclusions
Robust vascular development occurs during implantation and early placentation of normal pregnancies. Studies to define the extent and mechanisms by which defects in vascularity contribute to human implantation failure and early miscarriage need to be undertaken.
Springer