[HTML][HTML] Purification of apolipoprotein E attenuates isoform-specific binding to β-amyloid
MJ LaDu, TM Pederson, DE Frail, CA Reardon… - Journal of Biological …, 1995 - ASBMB
Apolipoprotein E (apoE), particularly the e4 allele, is genetically linked to the incidence of
Alzheimer'disease. In vitro, apoE has been shown to bind β-amyloid (Aβ), an amyloidogenic
peptide that aggregates to form the primary component of senile plaques. In previous work,
we demonstrated that apoE3 from tissue culture medium binds to Aβ with greater avidity
than apoE4 (LaDu, MJ, Falduto, MT, Manelli, AM, Reardon, CA, Getz, GS, and Frail, DE
(1994) J. Biol. Chem. 269, 23403-23406). This is in contrast to data using purified apoE …
Alzheimer'disease. In vitro, apoE has been shown to bind β-amyloid (Aβ), an amyloidogenic
peptide that aggregates to form the primary component of senile plaques. In previous work,
we demonstrated that apoE3 from tissue culture medium binds to Aβ with greater avidity
than apoE4 (LaDu, MJ, Falduto, MT, Manelli, AM, Reardon, CA, Getz, GS, and Frail, DE
(1994) J. Biol. Chem. 269, 23403-23406). This is in contrast to data using purified apoE …
