[HTML][HTML] The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor
J Ruiz, D Kouiavskaia, M Migliorini, S Robinson… - Journal of lipid …, 2005 - ASBMB
Apolipoprotein E (apoE) associates with lipoproteins and mediates their interaction with
members of the LDL receptor family. ApoE exists as three common isoforms that have
important distinct functional and biological properties. Two apoE isoforms, apoE3 and
apoE4, are recognized by the LDL receptor, whereas apoE2 binds poorly to this receptor
and is associated with type III hyperlipidemia. In addition, the apoE4 isoform is associated
with the common late-onset familial and sporadic forms of Alzheimer's disease. Although the …
members of the LDL receptor family. ApoE exists as three common isoforms that have
important distinct functional and biological properties. Two apoE isoforms, apoE3 and
apoE4, are recognized by the LDL receptor, whereas apoE2 binds poorly to this receptor
and is associated with type III hyperlipidemia. In addition, the apoE4 isoform is associated
with the common late-onset familial and sporadic forms of Alzheimer's disease. Although the …
