[HTML][HTML] A Direct Regulatory Role for Troponin T and a Dual Role for Troponin C in the Ca2+ Regulation of Muscle Contraction (∗)
JD Potter, Z Sheng, BS Pan, J Zhao - Journal of Biological Chemistry, 1995 - ASBMB
Troponin (Tn), containing three subunits: Ca 2+ binding (TnC), inhibitory (TnI), and
tropomyosin binding (TnT), plays a crucial role in the Ca 2+ regulation of vertebrate striated
muscle contraction. These three subunits function by interacting with each other and with the
other thin filament proteins. Previous studies suggested that the primary role of TnT is to
anchor the TnI• TnC complex to the thin filament, primarily through its interactions with TnI
and tropomyosin. We propose here a new role for TnT. Our results indicate that, when TnT is …
tropomyosin binding (TnT), plays a crucial role in the Ca 2+ regulation of vertebrate striated
muscle contraction. These three subunits function by interacting with each other and with the
other thin filament proteins. Previous studies suggested that the primary role of TnT is to
anchor the TnI• TnC complex to the thin filament, primarily through its interactions with TnI
and tropomyosin. We propose here a new role for TnT. Our results indicate that, when TnT is …
