Inhibition of CD1d1‐mediated antigen presentation by the vaccinia virus B1R and H5R molecules
European journal of immunology, 2006•Wiley Online Library
Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals
against the causative agent of smallpox (variola virus), but it also uses a number of
strategies meant to evade or blunt the host's antiviral immune response. Natural killer T
(NKT) cells are a subset of immunoregulatory CD1d‐restricted T lymphocytes believed to
bridge the innate and adaptive immune responses. It is shown here that the VV‐encoded
molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d‐mediated antigen …
against the causative agent of smallpox (variola virus), but it also uses a number of
strategies meant to evade or blunt the host's antiviral immune response. Natural killer T
(NKT) cells are a subset of immunoregulatory CD1d‐restricted T lymphocytes believed to
bridge the innate and adaptive immune responses. It is shown here that the VV‐encoded
molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d‐mediated antigen …
Abstract
Vaccinia virus (VV) has been most commonly used as the vaccine to protect individuals against the causative agent of smallpox (variola virus), but it also uses a number of strategies meant to evade or blunt the host's antiviral immune response. Natural killer T (NKT) cells are a subset of immunoregulatory CD1d‐restricted T lymphocytes believed to bridge the innate and adaptive immune responses. It is shown here that the VV‐encoded molecules, B1R and H5R, play a role in the ability of VV to inhibit CD1d‐mediated antigen presentation to NKT cells. These are the first poxvirus‐encoded molecules identified that can play such a role in the evasion of an important component of the innate immune response.
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