Dual actions of prostacyclin (PGI2) on the rat pregnant uterus
KI Williams, KEH El-Tahir, E Marcinkiewicz - Prostaglandins, 1979 - Elsevier
Using strips of rat pregnant uterus, treated with indomethacin to suppress spontaneous
contractility, the oxytocic activity of prostacyclin was compared with other prostaglandins. A
prostacyclin concentration of 32 ng/ml elicited uterine contractions in all experiments. In this
respect prostacyclin was 80 times more active than 6-oxo-PGF 1α but less active than PGE 2
or PGF 2α. Apart from a direct stimulant effect, prostacyclin also exhibited an indirect
potentiating action. In threshould concentrations prostacyclin caused a 3-fold potentiation of …
contractility, the oxytocic activity of prostacyclin was compared with other prostaglandins. A
prostacyclin concentration of 32 ng/ml elicited uterine contractions in all experiments. In this
respect prostacyclin was 80 times more active than 6-oxo-PGF 1α but less active than PGE 2
or PGF 2α. Apart from a direct stimulant effect, prostacyclin also exhibited an indirect
potentiating action. In threshould concentrations prostacyclin caused a 3-fold potentiation of …
