The effects of prostacyclin (PGI2) on tissues which detect prostaglandins (PG's)
C Omini, S Moncada, JR Vane - Prostaglandins, 1977 - Elsevier
The effects of prostacyclin (PGI 2) and its stable metabolite 6-oxo-PGF 1α on various
bioassay tissues are compared with those of PGE 2 and PGF 2α, using the cascade
superfusion method. On vascular smooth muscle, PGI 2 caused relaxation of all tissues
tested except the rabbit aorta. PGE 2 relaxed rabbit coeliac and mesenteric artery but
contracted bovine coronary artery and had no effect on rabbit aorta. 6-oxo-PGF 1α was
ineffective at the concentrations tested. On gastro-intestinal smooth muscle, PGI 2 contracted …
bioassay tissues are compared with those of PGE 2 and PGF 2α, using the cascade
superfusion method. On vascular smooth muscle, PGI 2 caused relaxation of all tissues
tested except the rabbit aorta. PGE 2 relaxed rabbit coeliac and mesenteric artery but
contracted bovine coronary artery and had no effect on rabbit aorta. 6-oxo-PGF 1α was
ineffective at the concentrations tested. On gastro-intestinal smooth muscle, PGI 2 contracted …
