Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides
RJ Gryglewski, S Bunting, S Moncada, RJ Flower… - Prostaglandins, 1976 - Elsevier
Abstract Prostaglandin (PG) endoperoxides (PGG 2 and PGH 2) contract arterial smooth
muscle and cause platelet aggregation. Microsomes from pig aorta, pig mesenteric arteries,
rabbit aorta and rat stomach fundus enzymically transform PG endoperoxides to an unstable
product (PGX) which relaxes arterial strips and prevents platelet aggregation. Microsomes
from rat stomach corpus, rat liver, rabbit lungs, rabbit spleen, rabbit brain, rabbit kidney
medulla, ram seminal vesicles as well as particulate fractions of rat skin homogenates …
muscle and cause platelet aggregation. Microsomes from pig aorta, pig mesenteric arteries,
rabbit aorta and rat stomach fundus enzymically transform PG endoperoxides to an unstable
product (PGX) which relaxes arterial strips and prevents platelet aggregation. Microsomes
from rat stomach corpus, rat liver, rabbit lungs, rabbit spleen, rabbit brain, rabbit kidney
medulla, ram seminal vesicles as well as particulate fractions of rat skin homogenates …
