Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid
GJ Dusting, S Moncada, JR Vane - Prostaglandins, 1977 - Elsevier
The actions of prostacyclin (PGX) and several other derivatives of arachidonic acid were
examined on spiral strips of bovine coronary artery. The strips were contracted by PGE 2
and thromboxane A 2. Although PGH 2 usually caused a transient contraction followed by a
relaxation, a few strips were only contracted whilst others were only relaxed. Prostacyclin
invariably relaxed coronary artery strips. Sodium arachidonate usually relaxed the strips but
occasionally had no effect. Indomethacin increased the resting tone and abolished or …
examined on spiral strips of bovine coronary artery. The strips were contracted by PGE 2
and thromboxane A 2. Although PGH 2 usually caused a transient contraction followed by a
relaxation, a few strips were only contracted whilst others were only relaxed. Prostacyclin
invariably relaxed coronary artery strips. Sodium arachidonate usually relaxed the strips but
occasionally had no effect. Indomethacin increased the resting tone and abolished or …
