The effects of lipoxygenase metabolites of arachidonic acid on human myometrial contractility
PR Bennett, MG Elder, L Myatt - Prostaglandins, 1987 - Elsevier
The effects of the lipoxygenase products of arachidonic acid, 5-and 12-
hydroxyeicosatetraenoic acid (5-and 12-HETE) and leukotriene B 4 (LTB 4), on the
spontaneous contractility of lower uterine segment human myometrial strips obtained prior to
labour have been studied in vitro. 5-HETE gave a dose-dependent (10–500ng) increase in
both the rate of contractions and overall contractility of myometrial strips while 12-HETE and
LTB 4 had no effect at the same concentrations. Prostaglandin F 2 (50ng) contracted all …
hydroxyeicosatetraenoic acid (5-and 12-HETE) and leukotriene B 4 (LTB 4), on the
spontaneous contractility of lower uterine segment human myometrial strips obtained prior to
labour have been studied in vitro. 5-HETE gave a dose-dependent (10–500ng) increase in
both the rate of contractions and overall contractility of myometrial strips while 12-HETE and
LTB 4 had no effect at the same concentrations. Prostaglandin F 2 (50ng) contracted all …
