[HTML][HTML] G2/M Transition Requires Multisite Phosphorylation of Oncoprotein 18 by Two Distinct Protein Kinase Systems∗
N Larsson, H Melander, U Marklund… - Journal of Biological …, 1995 - ASBMB
Oncoprotein 18 (Op18) is a conserved cytosolic protein that is a target for both cell cycle and
cell surface receptor-regulated phosphorylation events. The four residues Ser 16, Ser 25,
Ser 38, and Ser 63 are all subject to cell cycle-regulated phosphorylation. Ser 25 and Ser 38
are targets for cyclin dependent kinases (CDKs), while Ser 16 and Ser 63 are
phosphorylated by an unidentified protein kinase. We have recently shown that induced
expression of a CDK target site-deficient mutant, Op18-S25A, S38A, blocks human cell lines …
cell surface receptor-regulated phosphorylation events. The four residues Ser 16, Ser 25,
Ser 38, and Ser 63 are all subject to cell cycle-regulated phosphorylation. Ser 25 and Ser 38
are targets for cyclin dependent kinases (CDKs), while Ser 16 and Ser 63 are
phosphorylated by an unidentified protein kinase. We have recently shown that induced
expression of a CDK target site-deficient mutant, Op18-S25A, S38A, blocks human cell lines …
