[HTML][HTML] Direct binding of integrin αvβ3 to FGF1 plays a role in FGF1 signaling
Integrins play a role in fibroblast growth factor (FGF) signaling through cross-talk with FGF
receptors (FGFRs), but the mechanism underlying the cross-talk is unknown. We discovered
that FGF1 directly bound to soluble and cell-surface integrin αvβ3 (KD about 1 μm).
Antagonists to αvβ3 (monoclonal antibody 7E3 and cyclic RGDfV) blocked this interaction.
αvβ3 was the predominant, if not the only, integrin that bound to FGF1, because FGF1 bound
only weakly to several β1 integrins tested. We presented evidence that the CYDMKTTC …
receptors (FGFRs), but the mechanism underlying the cross-talk is unknown. We discovered
that FGF1 directly bound to soluble and cell-surface integrin αvβ3 (KD about 1 μm).
Antagonists to αvβ3 (monoclonal antibody 7E3 and cyclic RGDfV) blocked this interaction.
αvβ3 was the predominant, if not the only, integrin that bound to FGF1, because FGF1 bound
only weakly to several β1 integrins tested. We presented evidence that the CYDMKTTC …
