[HTML][HTML] Dual functional roles of dentin matrix protein 1: implications in biomineralization and gene transcription by activation of intracellular Ca2+ store
K Narayanan, A Ramachandran, J Hao, G He… - Journal of Biological …, 2003 - ASBMB
Dentin matrix protein 1 (DMP1) is a bone-and teeth-specific protein initially identified from
mineralized dentin. Here we report that DMP1 is primarily localized in the nuclear
compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional
component for activation of osteoblast-specific genes like osteocalcin. During the early
phase of osteoblast maturation, Ca 2+ surges into the nucleus from the cytoplasm, triggering
the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated …
mineralized dentin. Here we report that DMP1 is primarily localized in the nuclear
compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional
component for activation of osteoblast-specific genes like osteocalcin. During the early
phase of osteoblast maturation, Ca 2+ surges into the nucleus from the cytoplasm, triggering
the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated …
