[HTML][HTML] Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX
S Liu, R Guo, LG Simpson, ZS Xiao… - Journal of Biological …, 2003 - ASBMB
Inactivating mutations of Phex cause X-linked hypophosphatemia (XLH) by increasing levels
of a circulating phosphaturic factor. FGF23 is a candidate for this phosphaturic factor.
Elevated serum FGF23 levels correlate with the degree of hypophosphatemia in XLH,
suggesting that loss of Phex function in this disorder results in either diminished degradation
and/or increased biosynthesis of FGF23. To establish the mechanisms whereby Phex
regulates FGF23, we assessed Phex-dependent hydrolysis of recombinant FGF23 in vitro …
of a circulating phosphaturic factor. FGF23 is a candidate for this phosphaturic factor.
Elevated serum FGF23 levels correlate with the degree of hypophosphatemia in XLH,
suggesting that loss of Phex function in this disorder results in either diminished degradation
and/or increased biosynthesis of FGF23. To establish the mechanisms whereby Phex
regulates FGF23, we assessed Phex-dependent hydrolysis of recombinant FGF23 in vitro …
