Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism
T Kawata, Y Imanishi, K Kobayashi, T Miki… - Journal of the …, 2007 - journals.lww.com
The importance of fibroblast growth factor 23 (FGF-23) in the pathogenesis of phosphate
wasting disorders has been established, but controversy remains about how parathyroid
hormone (PTH), which also stimulates urinary phosphate excretion, regulates the circulating
level of FGF-23. We found that the serum FGF-23 concentration was higher in PTH-cyclin D1
transgenic mice, a model of primary hyperparathyroidism, than in wild-type mice. The serum
FGF-23 concentration was significantly and directly correlated with serum PTH and calcium …
wasting disorders has been established, but controversy remains about how parathyroid
hormone (PTH), which also stimulates urinary phosphate excretion, regulates the circulating
level of FGF-23. We found that the serum FGF-23 concentration was higher in PTH-cyclin D1
transgenic mice, a model of primary hyperparathyroidism, than in wild-type mice. The serum
FGF-23 concentration was significantly and directly correlated with serum PTH and calcium …
