FGFR3 and FGFR4 do not mediate renal effects of FGF23
S Liu, L Vierthaler, W Tang, J Zhou… - Journal of the American …, 2008 - journals.lww.com
Abstract Fibroblast growth factor 23 (FGF23) is a phosphaturic factor that suppresses both
sodium-dependent phosphate transport and production of 1, 25-dihydroxyvitamin D [1, 25
(OH) 2 D] in the proximal tubule. In vitro studies suggest that FGFR3 is the physiologically
relevant receptor for FGF23 in the kidney, but this has not been established in vivo. Here,
immunohistochemical analysis of the mouse kidney revealed that the proximal tubule
expresses FGF receptor 3 (FGFR3) but not FGFR1, FGFR2, or FGFR4. Compared with wild …
sodium-dependent phosphate transport and production of 1, 25-dihydroxyvitamin D [1, 25
(OH) 2 D] in the proximal tubule. In vitro studies suggest that FGFR3 is the physiologically
relevant receptor for FGF23 in the kidney, but this has not been established in vivo. Here,
immunohistochemical analysis of the mouse kidney revealed that the proximal tubule
expresses FGF receptor 3 (FGFR3) but not FGFR1, FGFR2, or FGFR4. Compared with wild …
