Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute …
XW Meng, J Chandra, D Loegering… - Journal of Biological …, 2003 - ASBMB
Because the MAPK pathway plays important roles in cell proliferation and inhibition of
apoptosis, this pathway has emerged as a potential therapeutic target for solid tumors and
leukemia. At the present time there is little information about activation of this pathway and
the consequences of its inhibition in acute lymphocytic leukemia cells (ALL). In the present
study, constitutive MAPK pathway activation, as evidenced by phosphorylation of ERK1 and
ERK2, was observed in 8 of 8 human lymphoid cell lines and 33%(8: 24) of pretreatment …
apoptosis, this pathway has emerged as a potential therapeutic target for solid tumors and
leukemia. At the present time there is little information about activation of this pathway and
the consequences of its inhibition in acute lymphocytic leukemia cells (ALL). In the present
study, constitutive MAPK pathway activation, as evidenced by phosphorylation of ERK1 and
ERK2, was observed in 8 of 8 human lymphoid cell lines and 33%(8: 24) of pretreatment …
